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刘毅

作者: 时间:2014-11-20点击数:

刘毅,徐州医学院药理学博士后,南京大学理学博士,2011年11月15日进站,合作(联合培养导师)胡刚教授,计划研究方向:精神神经系统药物学

基本信息

性 别: 男 出生年月:1972年12月16日

籍 贯 :福建建瓯 民族: 汉

毕业院校:南京大学 一级学科: 生物学

学习经历

1992-1996 昆明理工大学 本科

2000-2003 中国矿业大学 硕士

2003-2006 南京大学 博士

工作经历

1996-2000 南平铝业有限公司 生产工艺管理工作

2006- 2014 徐州医学院 药学院副院长

发表论文

1.Yi Liu(通讯), Xiaobin Fu,Nuo Lan,Sai Li, jingzheng Zhang, Shuaishuai Wang, Cheng Li. Luteolin protects against high fat diet-induced cognitive deficits in obesity mice. Behavioural brain research. 2014, 267: 178-188

2.Ling Zhang,Sai Li, Mei Hong, Yu-qing Xu, Shuai-shuai Wang,Yi Liu(通讯), Yong Qian, and Jing Zhao. A colorimetric and ratiometric fluorescent probe for imaging of endogenous H2S in living cells and H2S determination in mouse hippocampus.Org Biomol Chem,DOI: 10.1039/C4OB00285G.

3. Yunsheng Xue, Youguang Zheng, Lin An, Yunyan Dou,Yi Liu*(通讯) .Density functional theory study of the structure–antioxidant activity of polyphenolic deoxybenzoins. Food Chemistry. 2014, 151, 198–206.

4.Yi Liu*(通讯), Xiaobin Fu, Lingshan Gou, Sai Li, Nuo Lan, Youguang Zheng and Xiaoxing Yin. L-Citrulline Protects Against Glycerol-Induced Acute Renal Failure in Rats. Renal Failure. 2013, 35(3), 367–373.

5.Yi Liu*(通讯), Lingshang Gou, Xiaobin Fu, Sai Li, Nuo Lan, Xiaoxing Yin, Protective effect of rutin against acute gastric mucosal lesions induced by ischemia-reperfusion.. Pharm Biol. 2013, 51(7), 914–919.

6.Yi Liu*(通讯), Xuemei Zhuang, Xiaoxing Yin, Lingshan Gou, Xin Ling, Xia Tian, Ling Liu, Youguang Zheng, Ling Zhang. Protective effects of nizofenone administration on the cognitive impairments induced by chronic restraint stress in mice. Pharmacology, Biochemistry and Behavior. 2013, 103(3), 474-480.

7.Yi Liu*(通讯), Genguang Jia , Lingshan Gou, Lingyan Sun, Xiaobin Fu, Nuo Lan, Sai Li, Xiaoxing Yin. Antidepressant-like effects of tea polyphenols on mouse model of chronicunpredictable mild stress. Pharmacology, Biochemistry and Behavior. 2013, 104, 27–32.

8.Yi Liu*(通讯), Xia Tian, Lingshan Gou, Lingyan Sun, Xin Ling, Xiaoxing Yin. Luteolin attenuates diabetes-associated cognitive decline in rats.Brain Research Bulletin.2013, 94, 23– 29.(中国博士后基金2012M521125)

9. Yunsheng Xue,Youguang Zheng,Ling Zhang,Wenya Wu,Ding Yu,Yi Liu*(通讯).Theoretical study on the antioxidant properties of 2' -hydroxychalcones: H-atom vs. electron transfer mechanism. J. Mol Model. 2013, 19, 3851-3862.

10. Lingyan Sun, Xia Tian, Lingshan Gou, Xin Ling, Ling Wang, Yan Feng, Xiaoxing Yin, andYi Liu*(通讯).Beneficial synergistic effects of concurrent treatment with theanine and caffeine against cerebral ischemia–reperfusion injury in rats.Can.J. Physiol. Pharmacol. 2013, 91, 562–569.

11. Xia Tian, Lingyan Sun, Lingshan Gou, Xin Ling, Yan Feng, Ling Wang, Xiaoxing Yin,Yi Liu*(通讯).Protective effects ofL-theanine on chronic restraint stress-induced cognitive impairments in mice. Brain research. 2013, 1503, 24– 32.(中国博士后基金2012M521125)

12.Yi Liu*(通讯), Lingyan Sun, Lingshan Gou 1, Genguang Jia, Xiaobin Fu, Sai Li, Nuo Lan, Xiaoxing Yin, Inhibitory Effect of Theanine on Hepatic and Renal Injury in Mice Exposed to Unpredictable Chronic Mild Stress. Latin American Journal of Pharmacy. 2013, 32 (1), 83-89.

13. Sai Li, Wenqi Meng, Xiaobin Fu, Li Liu, Jingzheng Zhang, Cong Cheng, Nuo Lan, Wen Cui,Yi Liu*(通讯).An Efficient and Practical Synthesis of Ropivacaine Hydrochloride under Ultrasound Irradiation. Latin American Journal of Pharmacy. 2013, 32 (8), 1258-1262.

14 Yunsheng Xue, Ling Zhang, Yanli Li, Ding Yu, Youguang Zheng,Lin An, Xuedong Gong andYi Liu*(通讯).A DFT study on the structure and radical scavenging activity of newly synthesized hydroxychalcones. J. Phys. Org. Chem. 2013, 26, 240-248.

15.Yi Liu*(通讯), Xuemei Zhuang, Xiaoxing Yin, Lingshan Gou, Xin Ling, Nuo Lan, Xiaobin Fu, Sai Li, Ling Zhang, Ling Liu. Development of an oral naproxen-loaded microemulsion with enhanced solubility and attenuated gastric mucosal ulceration. Latin American Journal of Pharmacy. 2012, 31(10), 1392-1398.

16.Yi Liu*(通讯), Lingshan Gou, Cui Yin, Xiaoxing Yin, Junnian Zheng. A preliminary study on protective effect of L-citrulline against ischemia- reperfusion induced gastric mucosal lesions in rat. Indian journal of Pharmacology. 2012, 44(1), 31-35.

17. Yunsheng Xue, Ling Zhang, Yanli Li, Ding Yu, Youguang Zheng, Lin An, Xuedong Gong,Yi Liu*(通讯).A DFT study on the structure and radical scavenging activity of newly synthesized hydroxychalcones. Journal of Physical Organic Chemistry. 2012, 26(3), 240-248.

18. Yunsheng Xue, Lin An , Youguang Zheng , Ling Zhang , Xuedong Gong , Yan Qian ,Yi Liu*(通讯).Structure and electronic spectral property of coumarin–chalcone hybrids: A comparative study using conventional and long-range corrected hybrid functional. Computational and Theoretical Chemistry. 2012, 981, 90–99.

19. Yunsheng Xue, YouguangZheng, Lin An, Ling Zhang, Yan Qian, Ding Yu, Xuedong Gong,Liu Yi*(通讯).A theoretical study of the structure-radical scavenging activity of hydroxychalcones. Computational and Theoretical Chemistry. 2012, 982, 74-83.

20.Yi Liu*(通讯), Xin Ling, Lingshang Gou, Xiaobin Fu, Sai Li, Nuo Lan. Protective effects of luteolin on restraint stress-induced liver damage in mice. Latin American Journal of Pharmacy, 2012, 31(7), 1027-31.

21.Yi Liu* (通讯), Genguang Jia, Xin Ling, Nuo Lan, Youguang Zheng, Sai Li, Ling Zhang, Ling Liu, Rongli Zhang, Yunsheng Xue. Decomposition of copper-amino acid complexes by oxalic acid dihydrate. Canadian Journal of Chemistry. 2012, 90(6), 557-559.

22. Genguang Jia,Yi Liu*(通讯), Youguang Zheng, Ling Zhang, Ling Liu, Xin Ling, Lingshan Gou, Cui Yin, Xuemei Zhuang. A novel preparation of L-citrulline and L-homocitrulline. The Chemical Society ofPakistan. 2012, 34(2), 451-454.

23.Yi Liu*(通讯),Xia Tian, Lingshan Gou, Xiaobin Fu, Sai Li, Nuo Lan, Xiaoxing Yin. Protective effect of L-citrulline against ethanol-induced gastric ulcer in rats. Environmental toxicology and pharmacology. 2012, 34, 280-287.

主持项目

1. 中国国家自然科学基金,81341084,mtor对糖尿病脑病db/db小鼠突触可塑性的调节作用以及木犀草素的保护机制,10万元,第一负责人,进行中。

2. 中国博士后科学基金第52批面上资助2012M521125,含有木犀草素结构的硫化氢供体药物的研制及其在阿尔茨海默病模型中的神经保护作用研究,2012-2014年,5万元,第一负责人,结题。

3. 江苏省博士后基金,1201036B,慢性炎症在肥胖状态下瘦素抵抗形成中的作用及木犀草素的干预作用,2012-2014年,3万元,第一负责人,基本完成。

4. 江苏省高校科研成果产业化推进项目,JHB2012-33,新型七氟烷静脉纳米乳的生产技术,2012-2014年,3万元,第一负责人,结题。

5. 江苏省研究生教育教学改革研究与实践课题,JGZZ12_097,以创业理念为先导,探索药学研究生“产学研”创新创业新模式,2012-2014年,2万元,第一负责人,进行中。

发表专著(论著)

申请专利

1.刘毅印晓星田霞够灵山庄雪梅郑友广张玲刘玲.一种L-瓜氨酸在制备抗胃溃疡药物中的应用.中国国家专利局,申请号201110264701.2

2.刘毅刘莉田霞李静李赛孟文琪崔文.一种免洗皮肤手微乳消毒液制剂及其制备方法.中国国家专利局,申请号2013010136306.5

3.刘毅印晓星贾根光刘莉陈效毅刘玲庄雪梅田霞凌心够灵山尹翠.一种(S)-2-芳基丙酸类非甾体抗炎药的拆分方法.中国专利局.申请号201110187132.6

4. 刘毅印晓星庄雪梅吕冬梅够灵山凌心蓝诺李赛付小彬崔文.一种五氟利多自微乳化纳米组合物及其制备方法.中国专利局.申请号201110307384.8

5.刘毅张玲李赛王涛刘莉李程孟文琪.基于黄酮结构的硫化氢供体衍生物及其在治疗神经炎症相关疾病中的应用.中国国家专利局,申请号201410279942.8

6.刘毅印晓星庄雪梅刘莉陈效毅张玲刘玲尹翠.七氟醚静脉微乳剂及其制备方法.中国国家专利局,申请号201010147359.3已授权

获得奖励

1刘毅,汤道权,张玲,印晓星,郑友广.校企协同创新机制下培养药学应用型创新人才模式的探索与实践.江苏省教学成果奖二等奖,江苏省教育厅.2013年

2刘毅,徐州市十大青年科技奖,中共徐州市委组织部、徐州市人力资源和社会保障局、徐州市科学技术协会,第四届徐州市青年科技奖, 2012年

3刘毅,刘毅、刘莉、张玲、缑灵山、印晓星、刘玲、尹翠.L-瓜氨酸制备新方法研究以及L-瓜氨酸对胃肾损伤防治作用研究.徐州市科技进步二等奖.徐州人民市政府,2013年

社会团体任职

江苏省麻醉与镇痛应用技术重点实验室麻醉与镇痛药物合成研究室主任,校新药与临床应用重点实验室执行主任,国家自然科学基金评议专家,2012年获得徐州市十大青年科技奖,现为江苏省“青蓝工程”中青年学术带头人、江苏省第八批“六大人才高峰”高层次人才培养项目获得者、江苏省徐州医学院“优秀人才”、江苏省药理学会常务理事、江苏省药理学会新药与临床前研究专业委员会秘书长、江苏省化学化工学会理事、徐州市化学化工学会副理事长、江苏恩华药业股份有限公司技术中心特聘研究员。

刘毅博士后出站证书

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